Condensins Regulate Meiotic DNA Break Distribution, thus Crossover Frequency, by Controlling Chromosome Structure
نویسندگان
چکیده
منابع مشابه
Condensins Regulate Meiotic DNA Break Distribution, thus Crossover Frequency, by Controlling Chromosome Structure
Meiotic crossover (CO) recombination facilitates evolution and accurate chromosome segregation. CO distribution is tightly regulated: homolog pairs receive at least one CO, CO spacing is nonrandom, and COs occur preferentially in short genomic intervals called hotspots. We show that CO number and distribution are controlled on a chromosome-wide basis at the level of DNA double-strand break (DSB...
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that interphase nuclei could be converted to mitotic University of Edinburgh chromosomes only if topoisomerase II was endoge-Institute of Cell and Molecular Biology nously present or added back after depletion of the King's Buildings extract. Edinburgh EH9 3JR More recently, a similar convergence of data from Scotland divergent approaches has revealed the importance of the SMC (structural maint...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.07.035